The current vaccines available (Pfizer and Moderna) are mRNA vaccines. They work by
injecting mRNA, which is like a blueprint, into your body. The mRNA tells your body
how to make a “spike protein” of the virus. This “spike protein” allows your immune
system to recognize it as a foreign protein and make antibodies against it, similar
to when your body makes antibodies to natural infections. This allows vaccinated
patients to gain protection (antibodies) without actually getting the infection.
The vaccines were ~95% effective in study volunteers. The trials did not include kidney
transplant patients or other immunocompromised patients. It is expected the vaccine
may produce fewer antibodies in transplant patients as compared to the general population
because of the anti-rejection (immunosuppressive) medications they are on. Data is
being collected in kidney transplant patients now.
Is The Vaccine Safe?
mRNA vaccines have been studied since 2011, but the COVID-19 vaccines are the first
mRNA vaccines to be authorized for use outside of a clinical trial.
The vaccines were tested in over 70,000 subjects (both studies combined). The majority
of adverse reactions were mild and similar to other vaccines, including headache and
flu-like symptoms, as the body builds an immune response.
You will not get COVID-19 infection from a vaccination.
Your vaccination center will also provide you with a consent regarding details prior
to vaccination.
Is The Vaccine Safe For Transplant Patients?
Transplant patients are on anti-rejection (immunosuppressive) medications and are
considered high risk of infections, including COVID-19. The American Society of Transplantation
(AST) states that the benefits of the vaccine outweigh the risks in transplant recipients
and states transplant patients should consider getting the vaccination when available.
Along with transplant recipients, it is highly recommended that family members and
other household contacts also receive the vaccine as soon it is available to them.
