Allogeneic Stem Cell Transplantation

Overview

Allogeneic hematopoietic stem cell transplants use donor stem cells to restore a patient’s marrow and blood cells. There are several ways donor stem cells can be used for this type of transplant. We perform all types of Allogeneic hematopoietic stem cell transplants, such as matched related (siblings) donor, matched unrelated donor or cord blood as one of the sources for matched unrelated donor stem cells. We also perform haploidentical (half matched related donor) transplant.  We work closely with NMDP to find a match from the registry, if siblings aren’t appropriately matched.

For matched unrelated donor our primary source of donor is from NMDP international donor registry. In the event a patient needs an Allogeneic transplant and does not have a matched sibling, we get the matched unrelated donor or cord blood by searching international registry of NMDP, Be The Match.

Our multidisciplinary team includes an HLA Lab, which is vital for matching a patient to potential donors. Learn more about why HLA typing is important by watching this video from Be The Match:

Who is a Candidate for a Stem Cell Transplant?

In general, patients with good performance status, adequate kidney function, and minimal comorbidity are eligible. The donor must also be in good health and meet blood donor standards.

High-dose chemotherapy and Allogeneic hematopoietic stem cell transplant is a treatment option for both patients with newly-diagnosed disease, and for those who have already received other treatments. Allogeneic transplant is primarily performed for patients with Leukemia.

The donor will have an evaluation for eligibility; if eligible, their stem cells will most likely to be collected from peripheral blood process. We do not usually obtain stem cells from bone marrow, rather obtain stem cells from the blood which is much easier on the donor. Once collected, the stem cells are frozen until used for the patient’s Allogeneic stem cell transplant.

Allogeneic transplants are a treatment option for: Hodgkin’s lymphoma, acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, aplastic anemia and myeloproliferative disease.

Challenges for Allogeneic transplant

  • Finding a suitable donor can be difficult.
  • Managing post-transplant graft versus host diseases (GVHD).

Advantage

  • The Allogeneic transplant recipient may achieve complete remission of the disease (blood cancer) following this type of transplant.
  • Measures are taken to prevent GVHD complications following these transplants.

You can read more about the Allogeneic transplant process from Be The Match.

A healthy donor is prepared for stem cell harvest with cytokines and growth factors.
Collection: stem cells are collected from the donor's bone marrow or peripheral blood
Processing: Bone marrow or blood is processed in the laboratory to isolate, concentrate, and prepare stem cells for storage.
Chemotherapy: Patients are treated with chemotherapy and/or radiation therapy to destroy unwanted cancer cells and develop bone marrow failure.
Infusion: Stem cells are infused into the unhealthy patient.
Maintain transplanted cells with immunosuppressant therapy

 

 

 

 

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