Esketamine Nasal Spray for Treatment Resistant Depression
If you’ve struggled with depression and tried two or more antidepressants for an adequate
dose and duration during your current illness, talk to your doctor to see if you have
treatment-resistant depression.
Esketamine Nasal Spray for Treatment Resistant Depression
Esketamine Nasal Spray for Treatment Resistant Depression
If you’ve struggled with depression and tried two or more antidepressants for an adequate
dose and duration during your current illness, talk to your doctor to see if you have
treatment-resistant depression.
What is it?
Esketamine is a prescription medicine used along with an antidepressant taken by mouth
for depression in adults, especially when other medications have failed.
Esketamine explained on WJBF NewsChannel 6's "Jennie"
The most commonly used antidepressants are thought to work by increasing levels of
the neurotransmitters serotonin, norepinephrine, and dopamine in the brain. Esketamine
works differently by targeting the N-methyl-D-aspartate (NMDA) receptor.
Benefits
In a short term clinical study of adults with treatment resistant depression, those
who used esketamine and an oral antidepressant experienced a greater reduction in
depression symptoms at four weeks compared to people who received a placebo and an
oral antidepressant.*
In a long term study after 16 weeks of therapy, those patients who stayed on esketamine
did better than those who stopped therapy.
* Defined as an improvement of at least 50% based on an overall score on a standardized
rating scale
What to Expect
Esketamine can only be administered in certified health care settings including our
clinic.
Nasal spray is administered by the patient under observation by clinical staff after
which there is a two hour observation period.
Esketamine is administered twice weekly for one month, then weekly for a month, then
treatments may be spaced out.
Your first visit will include a comprehensive psychiatric evaluation to determine
whether you may be a candidate for esketamine treatment.
Precautions
Esketamine is not for everyone. Talk to your doctor about your full medical history
including if you have a history of abusing prescription drugs, have a problem with
alcohol, and if you are or planning to become pregnant or breastfeed.
You will need to plan for rides to and from the clinic and you should not drive or
operate machinery until the next day following a restful sleep.
Talk to your doctor or call to schedule an appointment: 706-721-6597
Our Providers
Augusta University Medical Center specialists provide care and support throughout your entire healthcare journey.