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Esketamine Nasal Spray for Treatment Resistant Depression

Esketamine Nasal Spray for Treatment Resistant Depression

If you’ve struggled with depression and tried two or more antidepressants for an adequate dose and duration during your current illness, talk to your doctor to see if you have treatment-resistant depression.

Esketamine Nasal Spray for Treatment Resistant Depression

If you’ve struggled with depression and tried two or more antidepressants for an adequate dose and duration during your current illness, talk to your doctor to see if you have treatment-resistant depression.

What is it?

Esketamine is a prescription medicine used along with an antidepressant taken by mouth for depression in adults, especially when other medications have failed.

Photo of esketamine nasal spray

The most commonly used antidepressants are thought to work by increasing levels of the neurotransmitters serotonin, norepinephrine, and dopamine in the brain. Esketamine works differently by targeting the N-methyl-D-aspartate (NMDA) receptor.

  • In a short term clinical study of adults with treatment resistant depression, those who used esketamine and an oral antidepressant experienced a greater reduction in depression symptoms at four weeks compared to people who received a placebo and an oral antidepressant.*
  • In a long term study after 16 weeks of therapy, those patients who stayed on esketamine did better than those who stopped therapy.

* Defined as an improvement of at least 50% based on an overall score on a standardized rating scale

Esketamine can only be administered in certified health care settings including our clinic.

Nasal spray is administered by the patient under observation by clinical staff after which there is a two hour observation period.

Esketamine is administered twice weekly for one month, then weekly for a month, then treatments may be spaced out.

Your first visit will include a comprehensive psychiatric evaluation to determine whether you may be a candidate for esketamine treatment.

Esketamine explained on WJBF NewsChannel 6's "Jennie"

video thumbnail
Dr. McCall explains nasal spray for people with depression, suicidal thoughts

Read more

Esketamine is not for everyone. Talk to your doctor about your full medical history including if you have a history of abusing prescription drugs, have a problem with alcohol, and if you are or planning to become pregnant or breastfeed.

You will need to plan for rides to and from the clinic and you should not drive or operate machinery until the next day following a restful sleep. 

Talk to your doctor or call to schedule an appointment:
706-721-6597

 

Our Providers

Augusta University Medical Center specialists provide care and support throughout your entire healthcare journey.

Londino, Donna L., MD

Child and Adolescent Psychiatry

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