With cutting-edge stroke treatment and comprehensive care at Augusta University Health Advanced Comprehensive Stroke Center, our stroke experts deliver skilled and responsive stroke care for improved outcomes.
Volumn of alteplase given and door to alteplase times:
Stroke is most commonly caused by a clot blocking blood flow within an artery in the brain. Recombinant tissue plasminogen activator (alteplase) is the only FDA approved medication for the treatment of acute stroke. The goal of alteplase treatment is to dissolve the clot and reestablish blood flow to the brain. Alteplase is given through an IV in the arm over one hour. However, alteplase is only helpful if it is given within 4.5 hours of the onset and the sooner alteplase is given, the more likely that damage from the stroke can be avoided. Recognizing the signs of stroke and calling 911 increases the chances of alteplase treatment.
- the median door to alteplase time is 67 minutes (JAMA. 2014;311:1632-40)
- the average for IV alteplase use among all ischemic stroke patients is 7% (Circ Cardiovasc Qual Outcomes. 2013;6:543-549)
Stroke is often caused by atherosclerosis, a progressive disease of the arteries resulting in plaque deposits. These plaque deposits can cause a narrowing or stenosis in the carotid arteries, increasing the risk for stroke. Carotid endarterectomy is a surgical procedure performed to reduce the risk of stroke in patients with severe stenosis of the internal carotid artery, and history of a transient ischemic attack (TIA) or stroke, or other significant risk factors. Symptomatic carotid stenosis refers to patient with a recent TIA or stroke prior the endarterectomy. Asymptomatic carotid stenosis refers to patient without a recent TIA or stroke prior to endarterectomy.
Clipping and Coiling Mortality Rate:
The most common treatments for brain aneurysms are clipping and coiling. Clipping involves the surgical placement of small metal clip around the "neck" of the aneurysm to prevent bleeding. Coiling involves the filling of an aneurysm sac with material to prevent blood from entering the aneurysm. Aneurysm coiling is done by guiding a catheter from an artery in the leg to the site of the aneurysm.
Diagnostic Angiography 24 hour post procedure stroke or death rate:
Diagnostic angiography is a procedure physicians use to investigate abnormalities in blood vessels. Conditions including carotid stenosis, aneurysms, AVMs (arteriovenous malformations) and others are commonly characterized using diagnostic angiography.
Risk of cerebral angiography in the literature is 2.63% (Kaufmann TJ, Huston J, Mandrekar JN, et al: Complications of Diagnostic Cerebral Angiography: Evaluation of 19,826