Drug-Induced HepatitisHepatitis Inducida por Medicamentos

Drug-Induced Hepatitis

What is drug-induced hepatitis?

Drug-induced hepatitis is a redness and swelling (inflammation) of the liver that is caused by a harmful (toxic) amount of certain medicines.

The liver helps to break down certain medicines in your blood. If there is too much medicine in your blood for your liver to break down, your liver can become badly damaged. This can lead to drug-induced hepatitis.

What causes drug-induced hepatitis?

Drug-induced hepatitis is rare. It is caused when you have a harmful or toxic amount of some medicines, vitamins, herbal remedies, or food supplements.

In most cases you may be taking a medicine for several months before it reaches a toxic level and affects your liver. But the disease can also happen if you take too much of some medicines such as acetaminophen.

Many types of medicines may cause drug-induced hepatitis. These include:

  • Pain and fever medicines that have acetaminophen
  • Aspirin and over-the-counter pain and fever medicines (NSAIDs or nonsteroidal anti-inflammatory drugs) 
  • Anabolic steroids, man-made medicines that are like the male sex hormone testosterone
  • Some medicines used to treat bacterial infections (antibiotics)
  • Birth control pills (oral contraceptives)
  • Statins, used to lower cholesterol
  • Sulfa medicines, a type of antibiotic

Who is at risk for drug-induced hepatitis?

The risk for drug-induced hepatitis varies with each medicine.

You may be at higher risk for drug-induced hepatitis if you:

  • Have liver disease, such as from long-term alcohol use, HIV, or viral hepatitis
  • Drink alcohol and take medicines at the same time
  • Are older
  • Are a woman
  • Use long-acting or extended release medicines

What are the symptoms of drug-induced hepatitis?

Each person’s symptoms may vary. Symptoms may include:

  • Belly or abdominal pain
  • Tiredness and weakness
  • Fever
  • Nausea
  • Vomiting
  • Lack of appetite
  • Dark urine
  • Pale or clay-colored stools
  • Yellowing of the skin and eyes (jaundice)

The symptoms of drug-induced hepatitis may look like other health problems. Always see your health care provider to be sure.

How is drug-induced hepatitis diagnosed?

Your health care provider will look at your past health and give you a physical exam.

You may have some lab blood tests, including:

  • Liver function tests. These check for any redness and swelling (inflammation) or damage to the liver.
  • Complete blood count or CBC. Looks at the number and types of cells in your blood.
  • Bleeding time. Looks at how fast the small blood vessels in your skin close to stop you from bleeding.
  • Electrolyte panel. Checks to see if you have too many or too few minerals (electrolyte imbalance) in your blood.
  • Tests for other chemicals in your body
  • Drug screening tests

Your may also have the following tests:

  • Ultrasound (sonography). This is used to see your liver and check how blood is flowing through different blood vessels. High-frequency sound waves create images of your internal organs on a computer screen.
  • Liver biopsy. Small tissue samples are taken from your liver with a needle. These samples are checked under a microscope to find out the amount and type of liver damage you have.

How is drug-induced hepatitis treated?

You must stop taking the medicine that is causing the problem. You must also check your liver closely while it recovers. The liver is often able to heal itself.

Some medicines may cause a slight increase in liver enzymes without any symptoms. You may not need to stop using these medicines. Talk with your health care provider about the risks and benefits.

What are the complications of drug-induced hepatitis?

If you don’t stop taking the medicine that is causing the problem, your liver will become more damaged. It may not recover. If this happens, you will need a liver transplant.

Key points about drug-induced hepatitis

  • Drug-induced hepatitis is a redness and swelling (inflammation) of the liver.
  • It is a rare condition caused by harmful (toxic) amounts of certain medicines, vitamins, herbal remedies, or food supplements.
  • In most cases you may be taking a medicine for several months before it reaches a toxic level and affects your liver.  
  • You may also get the condition if you take too much of some medicines such as acetaminophen.
  • You must stop taking the medicine that is causing the disease.

Next steps

Tips to help you get the most from a visit to your health care provider:
  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.
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